Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Query Trace: Duval BD[original query] |
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Evaluation of a latex agglutination assay for the identification of Burkholderia pseudomallei and Burkholderia mallei
Duval BD , Elrod MG , Gee JE , Chantratita N , Tandhavanant S , Limmathurotsakul D , Hoffmaster AR . Am J Trop Med Hyg 2014 90 (6) 1043-6 Cases of melioidosis and glanders are rare in the United States, but the etiologic agents of each disease (Burkholderia pseudomallei and Burkholderia mallei, respectively) are classified as Tier 1 select agents because of concerns about their potential use as bioterrorism agents. A rapid, highly sensitive, and portable assay for clinical laboratories and field use is required. Our laboratory has further evaluated a latex agglutination assay for its ability to identify B. pseudomallei and B. mallei isolates. This assay uses a monoclonal antibody that specifically recognizes the capsular polysaccharide produced by B. pseudomallei and B. mallei, but is absent in closely related Burkholderia species. A total of 110 B. pseudomallei and B. mallei were tested, and 36 closely related Burkholderia species. The latex agglutination assay was positive for 109 of 110 (99.1% sensitivity) B. pseudomallei and B. mallei isolates tested. |
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